Which is better: Single or multiple egg transfer? Fresh or Frozen?

For IVF, multiple studies show single egg transfer is better than multiple eggs.

According to multiple studies, including a recent 2017 study from the University of Colorado and Duke University, transferring one, rather than multiple fertilized eggs doubles the chances of a healthy birth. IVF with multiple eggs increases the odds of having twins or multiples, which in turn increases the chances that the babies will be born premature and underweight. The University of Colorado and Duke University collaborative study is the largest to date to look at outcomes of pregnancies using fresh and frozen donor eggs. The Colorado and Duke study is the first comprehensive comparison of the two methods, comparing outcomes for 30,000 patients who underwent IVF between the years 2012 and 2014. It was also found that there was no significant clinical difference in the success rates between fresh or frozen embryos. Since the use of a frozen embryo rather than a fresh embryo is a simpler process, the research suggests that frozen embryo transfers are just as viable of a choice for implantation when making decisions regarding your IVF transfer.

While any pregnancy has risks, most risks are considerably increased with multiple birth. While single deliveries are associated with a 9% risk of low birth weight, a 2% risk of very low birth weight, and a 14% risk of a premature birth, these same risks increase to 57%, 9%, and 65% with twin birth. With triplet birth, these risks are 96%, 34%, and 97%, respectively, according to the Centers for Disease Control and Prevention. The risks of low birth weight and premature birth are not to be ignored as short term. They can cause numerous other long-term risks, which include prolonged hospitalization, mental disabilities, cerebral palsy, respiratory distress, visual issues, digestive disorders, hearing loss, jaundice, bleeding in the brain, neonatal death, and increased risks during adulthood such as adult death from heart disease. Currently, the CDC and the American Society for Reproductive Medicine’s (ASRM) guidelines recommend that only one embryo should be transferred at a time

Intended parents are often given the choice about the number of embryos to transfer, but they should not make this decision lightly or without extensive education on the subject. They should make their decision only after considering the all of the risks to infants and surrogate, their desire for multiple children, their finances, and their clinic’s experience with fresh and frozen embryos.

To be further educated about this topic, we have included several links of interest and education, including our sources:





Please feel free to contact us with any questions you may have on this subject. We are here to help and guide you throughout the entire process!

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